Association of Adverse Pregnancy Outcomes With Glyburide vs Insulin in Women With Gestational Diabetes

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Association of Adverse Pregnancy Outcomes With Glyburide vs Insulin in Women With Gestational Diabetes.

IMPORTANCE Glyburide is thought to be safe for use during pregnancy for treatment of gestational diabetes mellitus (GDM). However, there are limited data on the effectiveness of glyburide when compared with insulin as used in a real-world setting. OBJECTIVE To estimate the risk of adverse maternal and neonatal outcomes in women with GDM treated with glyburide compared with insulin. DESIGN, ...

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Adverse pregnancy outcomes in women with diabetes

Pregnancy affects both the maternal and fetal metabolism and even in nondiabetic women exerts a diabetogenic effect. Among pregnant women, 2 to 17.8% develop gestational diabetes. Pregnancy can also occur in women with preexisting diabetes, that can predispose the fetus to many alterations in organogenesis, growth restriction and the mother to some diabetes-related complications like retinopath...

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Acanthosis nigricans among women with gestational diabetes mellitus and risk of adverse pregnancy outcomes.

A canthosis nigricans (AN) is a cutaneous manifestation of insulin resistance (1). Among women with gestational diabetes mellitus (GDM), it is not known whether AN is associated with greater need for insulin therapy in pregnancy or adverse perinatal outcomes. We performed a prospective cohort study of consecutive women with GDM or impaired glucose tolerance and a singleton pregnancy referred to...

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Differences in pregnancy outcomes and characteristics between insulin- and diet-treated women with gestational diabetes

BACKGROUND Our aim was to evaluate the difference in pregnancy outcomes and characteristics between insulin- and diet-treated women with gestational diabetes (GDM). METHODS Retrospective analysis of the medical files from 2010-2013 of women with GDM diagnosed with the Carpenter & Coustan criteria attending two clinics, one in a university and another in a non-university hospital. Characterist...

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Serum Adiponectin in Women with Gestational Diabetes

Background &Objective: Adiponectin is an adipose tissue adipokin that may contribute to obesity and insulin resistantance. The aim of this study was to evaluate the associations between serum concentrations of adiponectin and insulin resistance in gestational diabetes (GDM).Materials & Methods: Serum adiponectin levels, fasting blood sugar (FBS), glycated hemoglobin (HbA1C), insulin levels and ...

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ژورنال

عنوان ژورنال: JAMA Pediatrics

سال: 2015

ISSN: 2168-6203

DOI: 10.1001/jamapediatrics.2015.74